Dapoxetine
DAPOXETINE
Overview:
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) specifically developed for the treatment of premature ejaculation (PE) in men.
Classification:
Selective serotonin reuptake inhibitor (SSRI)
Uses:
Used to treat premature ejaculation in adult men.
Improves control over ejaculation.
Enhances sexual satisfaction for both partners.
Helps reduce anxiety associated with premature ejaculation.
How It Works:
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI). It works by increasing serotonin activity in the central nervous system — particularly in areas of the brain and spinal cord that regulate ejaculatory reflexes.Serotonin (5-HT) is a neurotransmitter that plays a key role in inhibiting ejaculation. By blocking the reuptake of serotonin at the synapse, dapoxetine enhances serotonin signaling, which helps delay ejaculation, increase intravaginal ejaculatory latency time (IELT), and improve control over ejaculation.
Dosage:
As prescribed by your doctor.
Side Effects:
Nausea
Headache
Diarrhea
Insomnia (difficulty sleeping)
Fatigue
Increased sweating (hyperhidrosis)
Anxiety
Precautions:
Dapoxetine should be used with caution and only under medical supervision, especially in individuals with underlying health conditions. It is contraindicated in patients with significant heart problems, such as arrhythmias, heart failure, or a history of fainting, due to the risk of syncope (sudden loss of consciousness) and orthostatic hypotension (a drop in blood pressure when standing up). It should also not be used by those with moderate to severe liver impairment, and caution is advised in patients with kidney disease.
Disclaimer:
This content is for informational purposes only. Always consult a healthcare provider for medical advice and proper dosage.
Sildenafil Citrate
SILDENAFIL CITRATE
Overview:
Sildenafil citrate (commonly known by the brand name Viagra) is a medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH).
Classification:
Phosphodiesterase(PDE) inhibitors
Uses:
It relaxes blood vessels in the lungs, improving blood flow and reducing the workload on the heart.
It helps men achieve and maintain an erection by increasing blood flow to the penis when sexually stimulated.
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How It Works:
Sildenafil citrate is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). In the presence of sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum of the penis, activating guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). cGMP induces smooth muscle relaxation in the corpus cavernosum by decreasing intracellular calcium levels, leading to vasodilation and increased penile blood flow, resulting in erection. Sildenafil enhances erectile function by inhibiting the degradation of cGMP by PDE5, thereby prolonging its vasodilatory effects. It has minimal effect in the absence of sexual stimulation and does not directly cause penile erection.
Dosage:
As prescribed by your doctor.
Side Effects:
Headache
Nasal congestion
Flushing (warmth or redness in the face, neck, or chest)
Dyspepsia (indigestion or upset stomach)
Dizziness
Visual disturbances
Precautions
It is important to inform your doctors that you take sildenafil.Dose adjustment may be needed. Start with the lowest dose in severe impairment.Warn patients to seek emergency help for erections lasting >4 hours, which can lead to permanent damage.
Disclaimer:
This content is for informational purposes only. Always consult a healthcare provider for medical advice and proper dosage.
