Mesalazine

Mesalazine 500 mg Gastro-resistant Tablet

Mesalazine belongs to the group of aromatic amines and is used as an anti-inflammatory agent. It is primarily indicated for the treatment and maintenance of remission in Inflammatory Bowel Diseases (IBD) such as Ulcerative Colitis and, in some cases, Crohn’s Disease.

Unlike typical painkillers, Mesalazine works locally on the gut lining, reducing swelling, redness, and irritation, and helping prevent cytokine-induced flare-ups.

Key Therapeutic Benefits

Gut Inflammation: Directly targets the intestinal lining to reduce ulceration and irritation.

Maintenance Of Remission: Helps prolong symptom-free periods and reduce the frequency of flare-ups.

Rectal Bleeding: Helps manage symptoms such as urgency, bloody stools, and other inflammatory signs of ulcerative colitis.

Localized Action: The drug passes through the stomach and releases slowly in the colon, acting mainly on inflamed mucosal surfaces.

Route Of Administration-Dosageage:

I. Swallow Whole – Do not crush, break, or chew the tablets. The enteric coating protects the medicine from stomach acid and ensures delivery to the intestines.

II. Consistency – Do not skip doses, even if you feel better. Mesalazine works best when maintained at a steady level in the gut.

III. Fluids – Drink plenty of water daily to support kidney function.

IV. Food – Usually taken with meals, but always follow your doctor’s specific instructions.

Precautions

I. Note: Inform your doctor if you have a history of liver or kidney disease, or an allergy to aspirin (salicylates).

Kidney Monitoring: Regular blood tests may be required to monitor renal function.

Pregnancy & Breastfeeding: Use under medical supervision. Although often continued during pregnancy, professional evaluation is essential.

Potential Side Effects

Most patients tolerate Mesalazine well, but some may experience:

Mild indigestion or nausea

Occasional headaches

Bloating or gas

Change in urine color (usually harmless)

Serious reactions such as high fever or severe abdominal cramps require immediate medical attention.

Frequently Asked Questions (FAQs)

Q: How long does Mesalazine take to work?

A: Initial improvement may be seen within 1–2 weeks, but full control of symptoms may take 4–8 weeks of regular use.

Q: Can I stop taking Mesalazine once symptoms improve?

A: No. In conditions like Ulcerative Colitis, Mesalazine is used as long-term maintenance therapy. Stopping early may lead to a relapse.

Q: What does it mean if I see tablet fragments in my stool?

A: Occasionally, the outer shell of a delayed-release tablet may appear in stool after the drug has been absorbed. If frequent, consult your doctor.

Q: Can I take painkillers like Ibuprofen with Mesalazine?

A: Generally not recommended. NSAIDs like Ibuprofen or Naproxen may worsen intestinal inflammation. Paracetamol is usually a safer alternative.

Q: Does Mesalazine affect my immune system?

A: No. Unlike immunosuppressants, Mesalazine does not broadly suppress the immune system. It works locally in the gut with a favorable safety profile.