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Insulin degludec: a Long Acting Basal Insulin for Continuous Glycaemic Control
Insulin degludec, the ultra-long basal analog insulin, is one such advanced option. Diabetes management in all patients, irrespective of the age group, qualifies degludec for this use. Designed to mimic the secretion of endogenous basal insulin by the body, it provides a never-declining and predictable output of insulin that could reach much beyond 24 hours. This keeps the blood sugar under control between meals and throughout the night, hence reducing the severe incident of blood sugar fluctuations.
How it works.
By an ingenious mode of action, Insulin degludec achieves its ultra-long duration of action:
Multi-hexameric formation: Injection of this insulin product at subcutaneous level produces spontaneous self-assembly of insulin molecules forming stable multi-hexamers in the subcutaneous tissues.
Holding at a constant pace: Their rate of disintegration is very slow but sure; so, a slow release would enable the system to break down monomers of insulin one after the other into the bloodstream.
Kind of Peak Level Retarded: This stands apart from those traditional intermediate- and long-acting insulins: With Insulin Degludec, instead of the famous wave set in motion, the action profile is aeroplanidly flat. This implies a uniform functioning over a rather long time-delay of about 42 hours, thereby dodging the steep drops in blood glucose.
Main Clinical Gains
Twenty-four Hours Hands-on: Easy injection once daily for insulin offers the accommodation of a low base level hepatic glucose-amounts efficiently.
A Substantial Reduction in Hypoglyemia: This blunt, predictable level of release considerably reduces the frequency of low blood sugar events, especially nocturnal hypoglycemia.
Dosing Flexibility: Rachel should be ideally taken at the same time each day. However, its ultra-long duration of action permits safe dosing latitude should schedule interruptions occur, provided that at least 8 hours can be guaranteed between injections.
Improved HbA1c Management: When part of a tailored therapeutic regimen that includes balanced diet, ongoing exercise, and mealtime insulin if needed, Levemir supports steady achievement of desired long-term blood sugar levels.
Dosage and Administration
Injection Technique: Administer Rachel subcutaneously to the thigh, upper arm, or abdomen. Rotate injection sites within the chosen recommended region when administering each dose to reduce the risk of localized lipodystrophy, characterized by thickening or pitting of the skin.
Timing: Administer your daily dose once daily. However, if you forget to give your dose, please do so as soon as you can, and then maintain a gap of at least 8 hours before your next scheduled dose.
Never mix: Insulin Degludec cannot be mixed in the same syringe or pen cartridge. Mixing in syringe or pen cartridge with any other insulin formulation or other fluid will disrupt the pattern of the multihexamers released by this Basal analog.
Visual Check: The solution inside the pen or vial should always be completely clear and colorless. Do not use the insulin if it looks cloudy or darkened or has small clumps.
1. Some Frequently Asked Questions (FAQs)
What unique characteristics are associated with Insulin Degludec, setting it apart from other basal insulins like Glargine?
While both long-acting basal insulins, Insulin Degludec has much longer activity (~42 hours versus ~24 hours for standard Glargine), besides a very flat and stabilized release rate. This extended duration translates into higher daily dosing flexibility and a decreased clinical susceptibility to unforeseen hypoglycemia.
2. What should I do if my blood sugars drop too low (hypoglycemia)?
Symptoms of low blood sugar engulf various bodily statuses such as shakiness, sweaty skin, dizziness, accelerating heartbeat, and confusion. Immediately take a fast-acting carbohydrate (like glucose tablets or juice), wait 15 minutes, then recheck your blood sugar. If your blood sugar is still low (below 70 mg/dL), repeat the same process.
Q3: How do I keep my vials or pens of Insulin Degludec?
Unopened: Keep within a temperature range of 2°C to 8°C in the refrigerator. Do not freeze.
In-use: If pen or vial is to be kept around for further use, do so at room temperature (below 30°C). An in-use pen or vial must be discarded within 56 days, notwithstanding any insulin left in it.
Q4: Can Insulin Degludec be used for both Type 1 and Type 2 Diabetes?
Yes, Levemir is used as in insulin combination with a mealtime fast-acting insulin and as a basal component of established insulin-based treatment regimen for Type 1 Diabetes. For Type 2 Diabetes, it is used alone or as part of a basal therapy regimen.
5. Will I gain weight if I take levemir?
Insulin therapy can result in weight gain, which is really predicated on the notion that insulin does help your body’s cells better absorb and utilize glucose rather than letting it be excreted out through your urine. Work on portion control and stay physically active under the guidance of your healthcare provider to maintain stable weight.