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Dosage Forms and Strengths:
Leflunomide 10 mg / 20 mg Tablet
Rheumatoid Arthritis
Leflunomide is a Disease-Modifying Anti-Rheumatic Drug (DMARD) used primarily for treating adults with Rheumatoid Arthritis (RA) and Psoriatic Arthritis. Unlike conventional painkillers that only mask symptoms, it targets the underlying cause—overactive immune cells responsible for joint inflammation and bone erosion.
Key Therapeutic Benefits
Reduces Joint Damage: Slows the progressive destruction of joint structures.
Reduces Inflammation: Helps decrease swelling, stiffness, and tenderness in joints.
Improved Mobility: Enhances physical function and ease of daily activities.
Maintenance Therapy: Provides long-term disease control in autoimmune conditions.
Directions for Use of Leflunomide
Consistency: Take the medication daily at the same time to maintain steady blood levels.
Administration: Swallow the tablet whole with water. Do not crush or chew.
With or Without Food: Can be taken with or without meals; take after food if stomach discomfort occurs.
Patience for Results: Initial improvement may appear within 4–8 weeks, but maximum benefit may take up to 6 months. Do not discontinue without consulting your rheumatologist.
What to Look for Before Using Leflunomide
Boxed Warning (Liver Toxicity): Leflunomide may cause serious liver damage. Regular Liver Function Tests (LFTs) are required, typically every 4 weeks for the first 6 months.
Pregnancy Warning: Strictly contraindicated in pregnancy due to risk of severe birth defects. Women of childbearing potential must use effective contraception during and after treatment.
Alcohol Intake: Avoid or limit alcohol, as it increases the risk of liver toxicity.
Infection Risk: As an immunosuppressant, it may increase susceptibility to infections. Avoid exposure to contagious illnesses.
Common Side Effects
Most patients tolerate the drug well, but possible side effects include:
Diarrhea (most common)
Nausea or indigestion
Temporary hair loss (alopecia)
Mild hypertension
Skin rash or itching
Note: Seek immediate medical attention if you experience severe diarrhea or signs of jaundice (yellowing of skin/eyes).
Frequently Asked Questions (FAQs)
Q: Is Leflunomide a steroid?
A: No. It is a DMARD, not a steroid. Steroids provide quick relief, whereas Leflunomide works gradually to modify disease progression.
Q: Why are regular blood tests required?
A: Monitoring liver enzymes and white blood cell counts is essential due to its effects on the liver and immune system.
Q: Can I get vaccinated while taking Leflunomide?
A: Live vaccines (e.g., yellow fever, oral polio) should be avoided. Always consult your doctor before vaccination.
Q: How long does the drug stay in the body after stopping?
A: Leflunomide can remain in the body for months to years. A drug elimination (washout) procedure may be required in special cases (e.g., planning pregnancy).
Q: Can it be taken with other medications?
A: Yes, it is often used with NSAIDs or low-dose corticosteroids. Always confirm your medication plan with your healthcare provider.