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Obeticholic Acid tablet 5 mg/10 mg
Obeticholic acid is a second-line therapy used in modern medicine for Primary Biliary Cholangitis (PBC), a chronic liver disease involving gradual damage to the bile ducts. It acts as a Farnesoid X Receptor (FXR) agonist, reducing bile production and enhancing bile clearance, thereby lowering toxic bile acid levels.
Key Uses
Primary Biliary Cholangitis (PBC): Used in adult patients who do not respond adequately to Ursodeoxycholic Acid (UDCA) or cannot tolerate it.
Liver Protection: Helps reduce alkaline phosphatase (ALP) levels, an important marker of liver health.
Major Benefits
Targeted Action: Specifically activates the FXR receptor to regulate bile acid synthesis.
Slows Disease Progression: Helps protect liver cells and reduce risk of fibrosis and cirrhosis.
Improves Lab Markers: Significantly lowers ALP and bilirubin levels in PBC patients.
How to Take
Starting Dose: Typically 5 mg once daily, with dose adjustment based on clinical response and liver function tests.
Administration: Swallow the tablet whole with water; may be taken with or without food.
Consistency: Take at the same time each day for best results.
With Bile Acid Sequestrants: If taking cholestyramine or colesevelam, take Obeticholic Acid at least 5 hours before or after these medicines.
Important Safety Information
Critical Alert: Not recommended in advanced liver disease (decompensated cirrhosis).
Liver Monitoring: Regular blood tests are essential. Report symptoms like jaundice (yellowing of eyes/skin), abdominal swelling, or severe itching (pruritus) immediately.
Common Side Effects
- Itching (pruritus)
- Fatigue or weakness
- Abdominal pain
- Throat swelling or redness
Frequently Asked Questions (FAQs)
Q: Will Obeticholic Acid cure Primary Biliary Cholangitis?
A: No cure exists for PBC, but Obeticholic acid is effective in managing the disease and slowing its progression.
Q: What should I do if itching becomes severe?
A: Inform your doctor. Dose adjustment or additional treatment may be required to manage pruritus.
Q: Is it safe for all liver disease patients?
A: No. It is specifically for PBC and should not be used in advanced liver disease or complete bile duct obstruction. Always consult a hepatologist.
Q: How long will I need to take this medication?
A: PBC is a chronic condition, so treatment is usually long-term or lifelong. Do not stop without medical advice.
Q: Can I drink alcohol while taking Obeticholic Acid?
A: It is best to avoid alcohol, as it can further stress the liver.
