Letrozole

2.5 mg Letrozole Tablet

Letrozole is a non-steroidal hormone therapy belonging to the third-generation aromatase inhibitors. It is a targeted anti-tumor medicine used primarily to treat hormone receptor-positive breast cancer (both early-stage and advanced) in postmenopausal women. It works by reducing estrogen levels, thereby slowing or stopping the growth of estrogen-dependent tumors. In certain cases, it is also prescribed for ovulation induction in women with fertility disorders.

Key Indications

Breast Cancer Management (First or Post-Tamoxifen): Used as adjunct therapy before or after tamoxifen, following surgery with or without radiation therapy.

Ovulation Induction: Used off-label in women with infertility, especially those with Polycystic Ovary Syndrome (PCOS).

Recurrence Prevention: Helps reduce the risk of cancer relapse after initial treatment.

Guidelines for Use

Standard Dose: 2.5 mg once daily is the commonly prescribed dose.

Timing: Take at the same time each day to maintain consistent hormone suppression.

Administration: Swallow the tablet whole with water; it may be taken with or without food.

Duration: Treatment often continues for 5 years or longer, as advised by an oncologist.

Major Safety Checklist

Pregnancy Alert: Strictly contraindicated in pregnancy. Use only under medical supervision when prescribed for fertility.

Bone Health: Long-term use may reduce bone mineral density. Calcium supplements and DEXA scans may be recommended.

Cholesterol Monitoring: Regular checks are needed as it may increase cholesterol levels.

Caution with Activities: Avoid driving or operating machinery until you understand its effects (e.g., dizziness).

Common Side Effects

Most side effects are mild and improve over time:

• Hot flashes or sweating
• Joint, bone, or muscle pain (arthralgia)
• Fatigue or muscle weakness
• Dizziness or headache
• Hair thinning

Note: Seek immediate medical attention if you experience chest pain, blurred vision, or severe leg swelling.

Frequently Asked Questions (FAQs)

Q: Is Letrozole a chemotherapy drug?
A: No. It is a hormonal therapy, not traditional chemotherapy. It works by blocking the aromatase enzyme, reducing estrogen production.

Q: Why is Letrozole used in fertility treatment?
A: It increases Follicle-Stimulating Hormone (FSH), helping stimulate ovulation, especially in women with PCOS.

Q: Can I drink alcohol while taking Letrozole?
A: Occasional alcohol is generally acceptable, but it may worsen side effects like hot flashes, dizziness, or fatigue.

Q: What should I do if I miss a dose?
A: Take it if remembered within a few hours. If it’s close to the next dose, skip it—do not double dose.

Q: Does Letrozole cause weight gain?
A: Some women may notice mild weight changes or fluid retention. A healthy diet and regular exercise can help manage this.