Pevesca Plus Capsule 10’S

Alpha Lipoic Acid

600mg ALA 600mg Capsule

Alpha-Lipoic Acid (ALA) is a versatile and potent antioxidant, an organosulfur compound. Known as the “universal antioxidant” because it is both water- and fat-soluble, it works throughout the body to neutralize free radicals. Besides its protective effect, it also plays a key role in cellular energy production, assisting mitochondria in turning glucose into energy.

Major Health Benefits

Promotion of Nerve Health: Widely used in treating diabetic neuropathy symptoms such as tingling, burning sensation, and numbness in the hands and feet.

Regulation of Blood Sugar: Helps improve insulin sensitivity and supports better blood glucose utilization.

Making of Cellular Energy: Acts as a co-factor in the Citric Acid Cycle, thereby enhancing cellular metabolism.

Recycles Antioxidants: Helps regenerate other antioxidants like Vitamin C, Vitamin E, and Glutathione after they are depleted.

Use Instruction

Absorption Timing: For maximum bioavailability, take on an empty stomach—typically 30 minutes before meals or 2 hours after.

Dosage: Common therapeutic doses include 300mg or 600mg, taken once or twice daily. Always follow your healthcare provider’s advice.

Storage: Store in a cool, dry place away from sunlight to maintain stability of active ingredients.

Safety & Precautions

Clinical Note: Although generally well-tolerated, ALA can significantly lower blood sugar levels. Monitor carefully if you are on insulin or oral antidiabetic medications.

Alcohol Intake: Chronic alcohol use may cause thiamine (Vitamin B1) deficiency. Taking ALA in such cases may pose health risks—consult your doctor.

Thyroid Health: May interact with thyroid hormone therapies (e.g., Levothyroxine). Medical supervision is advised.

Surgery: Discontinue use at least 2 weeks before surgery due to its effect on blood glucose levels.

Common Side Effects

Most individuals tolerate ALA well, but some may experience:

• Mild nausea or stomach upset
• Dizziness or lightheadedness
• Rare skin rash or itching
• Temporary metallic taste in the mouth

Note: Keep a source of sugar handy to manage symptoms of low blood sugar such as sweating, confusion, or shaking.

Frequently Asked Questions (FAQs)

Q: Is Lipoic Acid the same as Omega-3 (alpha-linolenic acid)?
A: No. Both share the acronym ALA but are different. Alpha-Lipoic Acid is a sulfur-containing antioxidant, while Alpha-Linolenic Acid is an essential fatty acid found in flaxseed and fish oil.

Q: Can Lipoic Acid aid in weight loss?
A: Some studies suggest it may support weight management by reducing appetite and boosting metabolism, especially when combined with diet and exercise.

Q: Why should I take it on an empty stomach?
A: Food—especially mineral-rich foods—can reduce absorption. Taking it before meals ensures better bioavailability.

Q: How long does it take to see results for nerve pain?
A: Some may notice improvement within 3–5 weeks, but significant benefits are typically observed over 3–4 months with consistent use.

Q: Can my child take this supplement?
A: High doses may be unsafe for children. Use only under strict medical supervision.

Methylcobalamin

Vitamin B12 Methylcobalamin 1500 mcg Caps/Tab

Methylcobalamin is the most bioactive and powerful form of Vitamin B12, especially suitable for vegetarians. Compared to synthetic forms like cyanocobalamin, it is already in a body-ready state and acts more efficiently without requiring conversion in the liver. It is primarily essential for nerve health, brain function, and red blood cell formation.

Major Likely Health Benefits

Support the Nerves: Often recommended for neuropathy (especially in diabetes) and peripheral nerve pain. It helps regenerate nerve sheaths and improves nerve signal transmission.

Boost Energy: Supports DNA synthesis and red blood cell production, helping reduce fatigue and brain fog.

Support Cognitive Functions: Aids in memory, sleep regulation, and mental clarity.

Homocysteine Regulation: Helps lower homocysteine levels, supporting cardiovascular health.

For Usage Guide

Dosage: The usual dose is 25–75 mg per day. Higher doses may be gradually increased (in 25–50 mg increments) up to 300 mg per day over several months, depending on individual response and medical advice.

Adverse Effects and Interactions

Toxicity: Methylcobalamin has low toxicity. Excess amounts are usually excreted in urine due to its water-soluble nature.

Alcohol Interaction: Alcohol consumption may reduce absorption and effectiveness; avoid excessive intake.

Severe Adverse Effects

Although rare, monitor for:

Lightheadedness

Unusual neurological symptoms

Withdrawal Symptoms

Withdrawal symptoms may vary depending on associated medications and typically appear within hours to days, resolving over weeks.

Pregnancy and Lactation

Pregnancy: Use only under medical supervision.

Lactation: Small amounts may pass into breast milk, but generally considered safe under guidance.

Dosage Instructions for Special Populations

Newborns, Infants, and Lactating Mothers: Use only under strict medical advice.

Possible Side Effects

Methylcobalamin is generally well-tolerated, but some individuals may experience:

Mild nausea or stomach upset

Temporary dizziness

Headache

Occasional skin itching or rash

Frequently Asked Questions (FAQs)

Q: Why should I choose Methylcobalamin over Cyanocobalamin?

A: Methylcobalamin is the natural, active form of Vitamin B12. It stays longer in the body and works directly at the nervous system level without requiring conversion, making it more efficient and effective.

Q: Can I take it for general tiredness?

A: Yes, especially if fatigue is due to Vitamin B12 deficiency. Vegetarians and elderly individuals often benefit from supplementation.

Q: How long does it take to improve nerve pain?

A: Energy levels may improve within 1–2 weeks, while nerve repair (numbness/tingling) may take 4–8 weeks of consistent use.

Q: Will overdosing on Vitamin B12 pose a risk?

A: Generally no. Being water-soluble, excess Vitamin B12 is excreted. However, stick to recommended doses such as 1500 mcg daily unless advised otherwise.

Q: Are there any foods I should avoid while taking it?

A: No major restrictions. However, excess alcohol may interfere with absorption, so moderation is advised.

Pregabalin

The 75 mg capsule of pregabalin

Pregabalin is a potent medication that belongs to the group of gabapentinoids and which is increasingly used for epilepsy and neuropathic pain management. You will find its administration in the treatment of chronic neurogenous pain syndromes such as diabetic neuropathic pain, post-herpetic neuralgia (pain related to shingles), and fibromyalgia. This drug is also served as an add-on therapy in adult patients with certain types of seizures or to manage Generalized Anxiety Disorder (GAD).

Therapeutical Use

Neuropathic Pain: Cures long-term nerve pain from diabetic neuropathy, shingles, or spinal-cord injury. Nuromusculoskel-

Fibromylagia: Straightens out widespread muscle pain, tenderness, and joint pain from this chronic condition.

Epilepsy: Works by modifying other drugs and controlling one part of the partially partial seizures by balancing the firing of brain cells.

Anxiety: Alleviates obsessions, restlessness, and tension in Generalized Anxiety Disorder.

Mode of Action

Pregabalin works by modulating the calcium channels within the central nervous system. By joining the specific subunits of these channels, pregabalin serves to diminish excitation of several neurotransmitters (for example glutamate and substance P). In a sense, it helps in "calming" overactive or damaged nerves, which in turn slows the transmission of the pain signal to the brain and prevents the occurrence of unnecessary abnormal electric discharges which cause seizures.

Brief Specification

Active Ingredient: Pregabalin (USP/IP)

Drug Classification: Anticonvulsant / Gabapentinoid

Common Strengths: 25mg, 50mg, 75mg, 150mg, 300mg

Prescription Category: Schedule H (Prescription-Required)

Administration and Dosages

Method: Preferably swallow the capsule whole with water. Do not open, chew, or crush a capsule.

Food: pregabalin may be taken with or without food. If it tends to cause stomach upset, one may take medication with or after a meal.

Consistency: So as to get the best results, take your dose at the same time(s) each day so that a consistent concentration of medicine can be maintained in your bloodstream.

Side Effects

Most side effects caused by Pregabalin are mild and should gradually wane as your body gets used to them. These may include:

Dizziness and sleepiness

Dry mouth

Blurred vision

Weight gain (increased appetite)

Swelling in hands or feet (edema)

Inability to concentrate and memory lapses

If you have a serious mood change (depression), thoughts of suicide, or an allergic reaction suddenly becomes severe (face/tongue swelling), call for emergency medical help (call) immediately.

Precautions

Alcohol: Avoiding alcohol is suggested while taking Pregabalin because it can be particularly dangerous as it increases drowsiness and interferes with coordination.

Driving: You do not drive or operate heavy machinery until you know will not make you dizzy or drowsy.

Kidney Health: Dose adjustments should be made for patients who have renal impairment, and your doctor should be well- informed about your kidney status.

Discontinue: Pregabalin should never be stopped suddenly. If the patient abruptly stops pregabalin, symptoms of withdrawal, such as insomnia, nausea, and an increase in seizure numbers, can occur. The dose will be tapered down by the doctor gradually over at least one week.

Mental Health: Monitor for development of any unusual changes in mood or behavior, particularly at the outset of treatment.

Frequently Asked Questions (FAQs)

Q: How long does it take for Pregabalin to start to work?

Some patients may start feeling pain reduction within the first week. It may, however, take 2-4 weeks of reasonably regular usage to obtain the full benefits from taking pregabalin.

Q: Is Pregabalin for normal back pain?

It is quite specific for nerve pain and not your everyday muscular strain or typical headaches treatment; therefore, Pregabalin applies to chronic back pain only with the nerve's involvement confirmed by a doctor.(for example, sciatica)

Q: Is Pregabalin addictive?

Pregabalin has a potential for misuse and habituation if taken in higher amounts or for longer than prescribed. Always follow your doctor’s instructions explicitly and never share this medicine with anyone else.

Q: If I miss a dose, what should I do?

Administer the missed dose as soon as you remember. If, in case, it is very near to the scheduled dose, just skip that accidentally missed dose. Do not ever take a double dose for extra benefit.

Q: Will this drug affect fertility?

Data on Pregabalin and human fertility are scarce. If pregnant or breastfeeding or planning to be pregnant, you should seek guidance from your healthcare provider given the potential for risk to the fetus outweighing benefits.

Vitamin B6

Vitamin B6 (Pyridoxine) Tablets

Pyridoxine, an alternate term for Vitamin B6, is a water-soluble nutrient that belongs to the B-complex family. This vitamin acts as a significant co-enzyme for more than 100 important chemical reactions in the body. From the support of brain development to a strong immune system, Vitamin B6 serves as the basic role that weaves within how the body processes proteins, fats, and carbohydrates.

Therapeutic Uses & Benefits

Neurological Support: Vital to neurotransmitter synthesis (serotonin and dopamine) for mood and sleep regulatory behavior.

Hemoglobin Production: Facilitates the formation of red blood cells, thereby preventing certain anemia types.

Morning Sickness Relief: A common recommendation by obstetricians to ease nausea and vomiting during gestation.

Cardiovascular Health: Vitamin B6 is beneficial in regulating the homocysteine level in the bloodstream, an amino acid involved in heart concerns.

Boost Immunity: Makes antibodies produce stronger to help combat the body's inherent defense cells.

Product Description

Active Ingredient: Pyridoxine Hydrochloride (IP/USP).

Dosage: 10mg, 25mg, 50mg, and 100mg.

Category: Nutritional Supplement/ Vitamin B Complex.

Form: Tablets/ Capsules for oral administration.

How To Use?

Dose: As given by your physician. In general, the usual dose is once daily.

Method: Drink the tablet whole with water. The best time to take it is after a meal for maximum absorption and minishment of stomach upset.

Regular intake: Try to take the supplement at the same time of the day to maintain steady supply in your body'.

Possible Side Effects

While B6 is considered safe at the recommended doses, the use of high doses for a long time can lead to nausea or stomach pain, temporary appetite change, headache, or drowsiness.

Note: Extremely high doses (past 200mg daily for an extended amount of time) may result in peripheral neuropathy (tingling or numbness in the hands and feet).

You should stop taking Vitamin B6 and consult your healthcare provider if that happens.

Precautions/Concerns/Vitamin B6 Drug Interaction: Vitamin B6 can interfere with drugs such as Levodopa and Altretamine.

Pre-existing conditions: Mention kidney and chronic ulcer issues to your doctor.

Pregnancy: Typically used for morning sickness, vitamin B6 availability must be legislated by professionals.

FAQs

Q: Do I get enough Vitamin B6 from my diet?

Yes, getting most of their needs from chickpeas, tuna, salmon, and poultry, and bananas is fine for most people. Nonetheless, those with absorption problems, kidney disease, or certain genetic disorders might need to rely on a supplement.

Q: Will Vitamin B6 help my PMS/PMT symptoms?

There are some studies showing that Vitamin B6 is effective in alleviating some of the emotional symptoms of Premenstrual Syndrome, such as irritability and bloating, because emotional symptoms could well result from a serious hormonal imbalance.

Q: What is the difference between Pyridoxine and Pyridoxal 5-phosphate (P5P)?

Pyridoxine is the most frequently used form available in supplements that are then made in the liver into the active "co-enzyme" form of the body and are useful in deficiencies.

Q: Will vitamin B6 help to get sleep?

Have adequate levels of it so that it can help to keep the sleep-wake cycle healthy as B6 would be involved in producing melatonin (the sleep hormone) and serotonin.

Q: Should I take Vitamin B6 on an empty stomach?

You could also bring it down on an empty stomach; it is in the refrigerator and does not retain the sign of it. To avoid mild nausea that is very common with several B-vitamins when not eaten with a food meal, however, the general recommendation would still be to eat it with a full meal.