Pregabel-Plus

Alpha Lipoic Acid

600mg ALA 600mg Capsule

Alpha-Lipoic Acid (ALA) is a versatile and potent antioxidant, an organosulfur compound. Known as the “universal antioxidant” because it is both water- and fat-soluble, it works throughout the body to neutralize free radicals. Besides its protective effect, it also plays a key role in cellular energy production, assisting mitochondria in turning glucose into energy.

Major Health Benefits

Promotion of Nerve Health: Widely used in treating diabetic neuropathy symptoms such as tingling, burning sensation, and numbness in the hands and feet.

Regulation of Blood Sugar: Helps improve insulin sensitivity and supports better blood glucose utilization.

Making of Cellular Energy: Acts as a co-factor in the Citric Acid Cycle, thereby enhancing cellular metabolism.

Recycles Antioxidants: Helps regenerate other antioxidants like Vitamin C, Vitamin E, and Glutathione after they are depleted.

Use Instruction

Absorption Timing: For maximum bioavailability, take on an empty stomach—typically 30 minutes before meals or 2 hours after.

Dosage: Common therapeutic doses include 300mg or 600mg, taken once or twice daily. Always follow your healthcare provider’s advice.

Storage: Store in a cool, dry place away from sunlight to maintain stability of active ingredients.

Safety & Precautions

Clinical Note: Although generally well-tolerated, ALA can significantly lower blood sugar levels. Monitor carefully if you are on insulin or oral antidiabetic medications.

Alcohol Intake: Chronic alcohol use may cause thiamine (Vitamin B1) deficiency. Taking ALA in such cases may pose health risks—consult your doctor.

Thyroid Health: May interact with thyroid hormone therapies (e.g., Levothyroxine). Medical supervision is advised.

Surgery: Discontinue use at least 2 weeks before surgery due to its effect on blood glucose levels.

Common Side Effects

Most individuals tolerate ALA well, but some may experience:

• Mild nausea or stomach upset
• Dizziness or lightheadedness
• Rare skin rash or itching
• Temporary metallic taste in the mouth

Note: Keep a source of sugar handy to manage symptoms of low blood sugar such as sweating, confusion, or shaking.

Frequently Asked Questions (FAQs)

Q: Is Lipoic Acid the same as Omega-3 (alpha-linolenic acid)?
A: No. Both share the acronym ALA but are different. Alpha-Lipoic Acid is a sulfur-containing antioxidant, while Alpha-Linolenic Acid is an essential fatty acid found in flaxseed and fish oil.

Q: Can Lipoic Acid aid in weight loss?
A: Some studies suggest it may support weight management by reducing appetite and boosting metabolism, especially when combined with diet and exercise.

Q: Why should I take it on an empty stomach?
A: Food—especially mineral-rich foods—can reduce absorption. Taking it before meals ensures better bioavailability.

Q: How long does it take to see results for nerve pain?
A: Some may notice improvement within 3–5 weeks, but significant benefits are typically observed over 3–4 months with consistent use.

Q: Can my child take this supplement?
A: High doses may be unsafe for children. Use only under strict medical supervision.

Folic Acid

Folic Acid 5mg Tablet

Folic Acid, presenting as Vitamin B9, is a key B-complex vitamin being water-soluble, helping in the synthesis of DNA and the normal maturation of red blood cells (RBCs). The characteristic nature of folic acid lies in its use for the treatment and the prevention of Folate Deficiency Anemia. It is well known globally for its powers to support a healthy pregnancy, among other vital functions. By keeping folate levels good, the medicine stops neural tube defects (NTDs) from forming in developing fetuses and maintains normal neurological health.

Key Therapeutic Uses

Anemia Management: Treats specifically megaloblastic anemia resulting from either poor dietary intake or malabsorption of folate.

Prenatal Support: Essential before pregnancy occurs and during the early stages to protect offspring from having a central nervous system defect (eg, spina bifida).

Methotrexate Adjunct: It is used along with some of the drugs used for arthritis or psoriasis to reduce gastrointestinal and liver side effects.

Cellular Repair- Plays an essential role in rapid cellular division and growth, particularly during childhood and pregnancy.

Product Highlights

High Potency Formula- Containing 5mg active Folic Acid per tablet only.

Rapid Absorption- Designed with good bioavailability for rapid entry into a person's blood.

Physician Endorsed- needed in prenatal care as pat of the extremities of finish carei in the realm of various blood maladies.

Directions for Use

Dosage: Normally, take one 5 mg tablet orally, daily, or as directed after conducting your blood test results in consultation with your physician.

Timing: Take it with or without food. To enhance benefits from consistent levels of the substance throughout the blood, it is suggested to take it within the same restarted interval every day.

Method: Swallow one tablet whole with a full glass of water.

Do not attempt to crush or chew the tablet.

Side Effects and Safety

Folic Acid is generally accepted well, but some individuals may experience some adverse reactions.

Nausea or mild loss of the appetite.

Gastrointestinal distress such as bloating or gas.

Bad taste in the mouth.

Occasionally, an allergic or anaphylactoid reaction like skin rash, itching, or swelling may happen.

Important Note: If you have vitamin B12 deficiency or Pernicious Anemia, take the necessary advice from your healthcare provider before beginning Folic Acid; taking Folic Acid alone sometimes might render a person vitamin B12 deficient, thus highlighting underlying neurologic troubles.

Caution and Drug Interactions

Liver and Kidney: Tell your healthcare provider if you experienced liver issues and if there is any history of kidney dialysis.

Drug Interactions: Some drugs, for example, anti-epileptic medications, antacids, and trimethoprim, can lower the uptake rate by the body of folate. These medications (Folic Acid) must be taken around 2 hours after any of the above drugs.

Alcohol: Heavy alcohol consumption reduces the absorption of folate and weakens the effect.

FAQs

Q: Can you tell me the best time to start taking Folic Acid if I'm planning on becoming pregnant?

Following the recommendations given by medical experts and studies closely, the production of folic acid should be done 1 to 3 months before conception, and at least during the first 12 weeks of pregnancy, which implies maximum safety for the baby's development.

Q: Can Folic Acid and Iron be taken together?

Yes, many doctors prescribe them together for more serious cases of anemia where a prescription of coal tablets is needed. Instead of lessening their efficiency, they generally enhance each other and improve overall blood health.

Q: Does Folic Acid make you gain weight?

No, Folic Acid is a vitamin and does not have a calorific value. It has never been proven in clinical studies that Folic Acid causes weight gain.

Q: Can I simply quit once my hemoglobin turns back to normal?

No, you should follow the course according to the advice and observation of your family physician. Even if your RBC (Red Blood Count) eventually comes back to the normal level, your body still might require re-pleting its folate stores so that you're not left with anemia again.

Q: What should I do if I forget to take the dose?

Missed dose must be taken as soon as it comes to your mind. However, if the next dose is almost due, you should forgo this one. And in no case should a "double" dose be ingested.

Methylcobalamin

Vitamin B12 Methylcobalamin 1500 mcg Caps/Tab

Methylcobalamin is the most bioactive and powerful form of Vitamin B12, especially suitable for vegetarians. Compared to synthetic forms like cyanocobalamin, it is already in a body-ready state and acts more efficiently without requiring conversion in the liver. It is primarily essential for nerve health, brain function, and red blood cell formation.

Major Likely Health Benefits

Support the Nerves: Often recommended for neuropathy (especially in diabetes) and peripheral nerve pain. It helps regenerate nerve sheaths and improves nerve signal transmission.

Boost Energy: Supports DNA synthesis and red blood cell production, helping reduce fatigue and brain fog.

Support Cognitive Functions: Aids in memory, sleep regulation, and mental clarity.

Homocysteine Regulation: Helps lower homocysteine levels, supporting cardiovascular health.

For Usage Guide

Dosage: The usual dose is 25–75 mg per day. Higher doses may be gradually increased (in 25–50 mg increments) up to 300 mg per day over several months, depending on individual response and medical advice.

Adverse Effects and Interactions

Toxicity: Methylcobalamin has low toxicity. Excess amounts are usually excreted in urine due to its water-soluble nature.

Alcohol Interaction: Alcohol consumption may reduce absorption and effectiveness; avoid excessive intake.

Severe Adverse Effects

Although rare, monitor for:

Lightheadedness

Unusual neurological symptoms

Withdrawal Symptoms

Withdrawal symptoms may vary depending on associated medications and typically appear within hours to days, resolving over weeks.

Pregnancy and Lactation

Pregnancy: Use only under medical supervision.

Lactation: Small amounts may pass into breast milk, but generally considered safe under guidance.

Dosage Instructions for Special Populations

Newborns, Infants, and Lactating Mothers: Use only under strict medical advice.

Possible Side Effects

Methylcobalamin is generally well-tolerated, but some individuals may experience:

Mild nausea or stomach upset

Temporary dizziness

Headache

Occasional skin itching or rash

Frequently Asked Questions (FAQs)

Q: Why should I choose Methylcobalamin over Cyanocobalamin?

A: Methylcobalamin is the natural, active form of Vitamin B12. It stays longer in the body and works directly at the nervous system level without requiring conversion, making it more efficient and effective.

Q: Can I take it for general tiredness?

A: Yes, especially if fatigue is due to Vitamin B12 deficiency. Vegetarians and elderly individuals often benefit from supplementation.

Q: How long does it take to improve nerve pain?

A: Energy levels may improve within 1–2 weeks, while nerve repair (numbness/tingling) may take 4–8 weeks of consistent use.

Q: Will overdosing on Vitamin B12 pose a risk?

A: Generally no. Being water-soluble, excess Vitamin B12 is excreted. However, stick to recommended doses such as 1500 mcg daily unless advised otherwise.

Q: Are there any foods I should avoid while taking it?

A: No major restrictions. However, excess alcohol may interfere with absorption, so moderation is advised.

Pregabalin

The 75 mg capsule of pregabalin

Pregabalin is a potent medication that belongs to the group of gabapentinoids and which is increasingly used for epilepsy and neuropathic pain management. You will find its administration in the treatment of chronic neurogenous pain syndromes such as diabetic neuropathic pain, post-herpetic neuralgia (pain related to shingles), and fibromyalgia. This drug is also served as an add-on therapy in adult patients with certain types of seizures or to manage Generalized Anxiety Disorder (GAD).

Therapeutical Use

Neuropathic Pain: Cures long-term nerve pain from diabetic neuropathy, shingles, or spinal-cord injury. Nuromusculoskel-

Fibromylagia: Straightens out widespread muscle pain, tenderness, and joint pain from this chronic condition.

Epilepsy: Works by modifying other drugs and controlling one part of the partially partial seizures by balancing the firing of brain cells.

Anxiety: Alleviates obsessions, restlessness, and tension in Generalized Anxiety Disorder.

Mode of Action

Pregabalin works by modulating the calcium channels within the central nervous system. By joining the specific subunits of these channels, pregabalin serves to diminish excitation of several neurotransmitters (for example glutamate and substance P). In a sense, it helps in "calming" overactive or damaged nerves, which in turn slows the transmission of the pain signal to the brain and prevents the occurrence of unnecessary abnormal electric discharges which cause seizures.

Brief Specification

Active Ingredient: Pregabalin (USP/IP)

Drug Classification: Anticonvulsant / Gabapentinoid

Common Strengths: 25mg, 50mg, 75mg, 150mg, 300mg

Prescription Category: Schedule H (Prescription-Required)

Administration and Dosages

Method: Preferably swallow the capsule whole with water. Do not open, chew, or crush a capsule.

Food: pregabalin may be taken with or without food. If it tends to cause stomach upset, one may take medication with or after a meal.

Consistency: So as to get the best results, take your dose at the same time(s) each day so that a consistent concentration of medicine can be maintained in your bloodstream.

Side Effects

Most side effects caused by Pregabalin are mild and should gradually wane as your body gets used to them. These may include:

Dizziness and sleepiness

Dry mouth

Blurred vision

Weight gain (increased appetite)

Swelling in hands or feet (edema)

Inability to concentrate and memory lapses

If you have a serious mood change (depression), thoughts of suicide, or an allergic reaction suddenly becomes severe (face/tongue swelling), call for emergency medical help (call) immediately.

Precautions

Alcohol: Avoiding alcohol is suggested while taking Pregabalin because it can be particularly dangerous as it increases drowsiness and interferes with coordination.

Driving: You do not drive or operate heavy machinery until you know will not make you dizzy or drowsy.

Kidney Health: Dose adjustments should be made for patients who have renal impairment, and your doctor should be well- informed about your kidney status.

Discontinue: Pregabalin should never be stopped suddenly. If the patient abruptly stops pregabalin, symptoms of withdrawal, such as insomnia, nausea, and an increase in seizure numbers, can occur. The dose will be tapered down by the doctor gradually over at least one week.

Mental Health: Monitor for development of any unusual changes in mood or behavior, particularly at the outset of treatment.

Frequently Asked Questions (FAQs)

Q: How long does it take for Pregabalin to start to work?

Some patients may start feeling pain reduction within the first week. It may, however, take 2-4 weeks of reasonably regular usage to obtain the full benefits from taking pregabalin.

Q: Is Pregabalin for normal back pain?

It is quite specific for nerve pain and not your everyday muscular strain or typical headaches treatment; therefore, Pregabalin applies to chronic back pain only with the nerve's involvement confirmed by a doctor.(for example, sciatica)

Q: Is Pregabalin addictive?

Pregabalin has a potential for misuse and habituation if taken in higher amounts or for longer than prescribed. Always follow your doctor’s instructions explicitly and never share this medicine with anyone else.

Q: If I miss a dose, what should I do?

Administer the missed dose as soon as you remember. If, in case, it is very near to the scheduled dose, just skip that accidentally missed dose. Do not ever take a double dose for extra benefit.

Q: Will this drug affect fertility?

Data on Pregabalin and human fertility are scarce. If pregnant or breastfeeding or planning to be pregnant, you should seek guidance from your healthcare provider given the potential for risk to the fetus outweighing benefits.

Pyridoxine Hydrochloride

Pyridoxine Hydrochloride (Vitamin B6) Tablets

Pyridoxine Hydrochloride is the hydrochloride salt form of Pyridoxine, a vital water-soluble Vitamin B-complex nutrient. It plays a key role in over 100 metabolic enzyme reactions, especially in protein metabolism. It is essential for neurotransmitter production (like serotonin), red blood cell formation, and maintaining a healthy nervous and immune system.

Indications

Vitamin B6 Deficiency: Treatment and prevention of nutritional deficiencies

Drug-Induced Neuropathy: Used with Isoniazid to prevent nerve damage

Vomiting in Pregnancy: Helps manage morning sickness (often with Doxylamine)

Sideroblastic Anemia: Supports hemoglobin synthesis

Metabolic Support: Helps manage homocysteine levels for heart health

Key Highlights

Neuro-Protective: Maintains myelin sheath integrity

Metabolic Regulator: Aids in energy production from nutrients

Mood & Sleep Support: Supports serotonin and melatonin synthesis

Dosage & Administration

Adult Dose: Typically 10–50 mg daily (higher for specific conditions)

Administration: Swallow whole with water; take after meals

What If I Miss a Dose?

Take it when remembered; skip if close to next dose

Do not double dose

Possible Side Effects

Nausea or stomach pain

Headache or drowsiness

Mild tingling or numbness (paraesthesia)

Loss of appetite

Precautions & Warnings

Neurological Monitoring: High doses (>200 mg/day) may cause sensory neuropathy

Levodopa Interaction: May reduce effectiveness in Parkinson’s treatment

Allergy: Inform doctor if allergic to B-complex vitamins

Lactation: Passes into breast milk—use under supervision

Frequently Asked Questions (FAQs)

Q: Can I take Pyridoxine without a prescription?
Yes, for general supplementation (OTC); higher doses need prescription

Q: Why is it given with TB medication?
Prevents nerve-related side effects of Isoniazid

Q: Does it help with PMS?
May improve mood symptoms—consult a doctor

Q: Is it safe in pregnancy?
Commonly used for nausea, but only under medical supervision

Q: Can diet provide enough Vitamin B6?
Foods like chickpeas, poultry, fish, bananas, and fortified cereals are good sources

Expert Advice

Storage: Store in a cool, dry place (below 25°C) away from sunlight

Patient Tip: Take at the same time daily; avoid excess alcohol

Disclaimer

This information is for educational purposes only and should not replace professional medical advice