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Obeticholic Acid activates receptors in the liver to reduce bile acid buildup and inflammation. It is used to treat primary biliary cholangitis and improve liver function in chronic liver disease. For more details kindly click on Medicine Salts below:
Obeticholic Acid
Obeticholic Acid tablet 5 mg/10 mg
Obeticholic acid is a second-line therapy used in modern medicine for Primary Biliary Cholangitis (PBC), a chronic liver disease involving gradual damage to the bile ducts. It acts as a Farnesoid X Receptor (FXR) agonist, reducing bile production and enhancing bile clearance, thereby lowering toxic bile acid levels.
Key Uses
Primary Biliary Cholangitis (PBC): Used in adult patients who do not respond adequately to Ursodeoxycholic Acid (UDCA) or cannot tolerate it.
Liver Protection: Helps reduce alkaline phosphatase (ALP) levels, an important marker of liver health.
Major Benefits
Targeted Action: Specifically activates the FXR receptor to regulate bile acid synthesis.
Slows Disease Progression: Helps protect liver cells and reduce risk of fibrosis and cirrhosis.
Improves Lab Markers: Significantly lowers ALP and bilirubin levels in PBC patients.
How to Take
Starting Dose: Typically 5 mg once daily, with dose adjustment based on clinical response and liver function tests.
Administration: Swallow the tablet whole with water; may be taken with or without food.
Consistency: Take at the same time each day for best results.
With Bile Acid Sequestrants: If taking cholestyramine or colesevelam, take Obeticholic Acid at least 5 hours before or after these medicines.
Important Safety Information
Critical Alert: Not recommended in advanced liver disease (decompensated cirrhosis).
Liver Monitoring: Regular blood tests are essential. Report symptoms like jaundice (yellowing of eyes/skin), abdominal swelling, or severe itching (pruritus) immediately.
Common Side Effects
- Itching (pruritus)
- Fatigue or weakness
- Abdominal pain
- Throat swelling or redness
Frequently Asked Questions (FAQs)
Q: Will Obeticholic Acid cure Primary Biliary Cholangitis?
A: No cure exists for PBC, but Obeticholic acid is effective in managing the disease and slowing its progression.
Q: What should I do if itching becomes severe?
A: Inform your doctor. Dose adjustment or additional treatment may be required to manage pruritus.
Q: Is it safe for all liver disease patients?
A: No. It is specifically for PBC and should not be used in advanced liver disease or complete bile duct obstruction. Always consult a hepatologist.
Q: How long will I need to take this medication?
A: PBC is a chronic condition, so treatment is usually long-term or lifelong. Do not stop without medical advice.
Q: Can I drink alcohol while taking Obeticholic Acid?
A: It is best to avoid alcohol, as it can further stress the liver.
At Gem Pharmacy, we make every effort to provide accurate, expert-written, and thoroughly reviewed information related to medicines. However, this information should not be considered a substitute for professional medical advice, diagnosis, or treatment from a qualified doctor.
The purpose of this information is to educate users and improve communication between patients and healthcare professionals. It should not be used to diagnose or treat any condition.
Always consult a certified healthcare professional before taking any medication.
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