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This medicine is a strong antibiotic combination made for the pediatric group and in patients who find it difficult for them to swallow solid tablets. It contains Amoxicillin, a penicillin group antibiotic, and Clavulanic Acid, a β-lactamase inhibitor. Together they act against various bacteria even resistant to an ordinary dose of amoxicillin.
Product Highlights
Synergistic activity: Clavulanic acid prevents bacteria from breaking down Amoxicillin, thus enhancing drug effectiveness.
Pediatric Friendly: Comes as the dry syrup containing mixed fruit flavor for easy administration to children.
Broad-spectrum: Active against middle ear infections (otitis media), respiratory infections (pharyngitis, tonsillitis, bronchitis, and pneumonia), and urinary tract infections (cystitis, urethritis).
High bioavailability: Enhances absorption by being administered just before a meal.
Therapeutic indications
This medicine is usually prescribed for the treatment of the following:
Infections of Ear, Nose, and Throat: Acute sinusitis and tonsillitis.
Infections of the Respiratory Tract: Bronchitis and community-acquired pneumonia.
Skin and Soft Tissue Infections: Infected bites, abscesses, and cellulitis.
Dental Abscesses: Severe abscesses in people with cellulitis extending from the face.
Urinary Tract Infections: Cystitis and urethritis.
Compositions & Mechanisms
Each 5 ml of reconstituted suspension contains the following ingredients:
Amoxicillin IP: 200 mg (as Trihydrate)
Clavulanic Acid IP: 28.5 mg (as Potassium Clavulanate)
Mechanism: Amoxicillin inhibits bacterial cell wall synthesis. This leads to cell death by binding to penicillin-binding proteins. Some bacteria produce an enzyme called beta-lactamase to defend themselves. Clavulanic Acid irreversibly binds to the enzyme, thereby allowing Amoxicillin to exercise its antibacterial effect.
How To Use (Dry Syrup Reconstitution)
Shake the bottle vigorously before opening, to loosen the powder.
Add sterile water (usually provided together with the pack) up to the ring mark on the bottle.
Shake the bottle vigorously until complete dissolution.
If the level decreases after vigorous shaking, add more water until it rises back to the mark.
Storage: Ensure that the reconstituted suspension remains refrigerated between $2^\circ\text{C}$ and $8^\circ\text{C}$. Discard any unused cilastatin after about 7-10 days.
Safety Information & Warnings
Penicillin Allergy: Do not use if the patient has a known history of severe allergic reactions (anaphylaxis) to penicillins or cephalosporins.
Liver Health: Use caution in cases of preexisting hepatic impairment.
Mononucleosis: Avoid using it in instances when “Mono” is really suspected, as it may trigger dissemination of skin rash.
Phenylketonuria (PKU): Many oral suspensions contain aspartame. Check the label in case the patient has PKU.
Frequently Asked Questions (FAQs)
Q: My child started feeling better within 2 days. Shall I stop the medication?
A: No! Please make sure your child finishes the full course of medication according to what has been prescribed by your child’s doctor. Suddenly stopping the medicine can allow the most resistant bacteria to survive, leading to treatments that are the least effective against future infections.
Q: Can I repeat the dose if my child vomited right after the first dose?
A: If the child vomits within 30 minutes after taking the medication then wait for some time and give the child the exact same dose. There is no need to give the same once again if vomiting triggers after more than 30 minutes.
Q: Can this suspension in any manner lead to diarrhea?
A: Yes, diarrhea often occurs with Clavulanic Acid. To lessen the upset stomach, give the dose during mealtime. Look out for severe, watery, or bloody stools and make sure you contact your pediatric care provider immediately.
Q: How do I store the drug?
A: Before reconstitution, store the dry powder in a dry cool place; after the medicine is constituted with water, store it within a day or two preferably in a refrigerator.
