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Tablet of Brivaracetam 50mg
Brivaracetam is a strong candidate for the fourth-generation anti-epileptic drugs (AEDs) that are used for focal seizures (seizures that start in one part of the brain). It belongs to the racetam class of medications. Racetams are often used when other seizure medicines are not able to control the electrical activity in the brain properly.
Indicated for use in adults and children as young as a month old, Brivaracetam reduces the frequency of attacks by increasing the performance of the inhibitory system, thus enhancing the stability of the electrical signals in the nerve cells.
Merits
High degree of specific therapeutic action: this agent effectively works by acting on the synaptic vesicle protein 2A (SV2A) situated in the brain that regulates the release of neurotransmitters.
Rapid Onset: The maximum plasma concentration is achieved within 1 hr, signifying rapid action.
Flexible Adjunctive Therapy: It can be used as a monotherapy or in combination with other AEDs.
Weight Neutrality: Usually does not create such large weight changes as is some for the older epilepsy medications.
The Mechanism of Action
Brivaracetam acts by sticking itself to a certain protein, SV2A, present on the cells’ surfaces. By binding to this site, it dampens the excessive electrical discharges that would otherwise give way to seizures. Unlike Levetiracetam, its parent among the UCB pipeline, it binds to SV2A with a higher affinity, thus hypothetically making it more efficient in seizure control than the latter at lower doses.
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Dosage of Brivaracetam
Dosing: Start a 25mg bid and titrate at weekly intervals with dosing to be progressively increased by 25mg bid until a maximum of 100mg bid.
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Compliance: It should be taken at a fixed time daily avoiding direct contact with sunlight where it maintains a constant level in the body system.
Take the tablet as a whole with water. Do not crush, chew, or split the tablet, as this could impact its absorption.
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Recommended food: May eat with or without food.
Common Side Effects
Brivaracetam, like all anticonvulsants, can cause some typical initial side effects when you get used to them:
- Dizziness or lightheadedness
- Drowsiness (Somnolence)
- Fatigue or unusual tiredness
- Nausea and vomiting
- Irritability or mood swings
Precautionary Note
Seek medical advice urgently if you experience a severe skin rash, swelling of the face, or thoughts of self-harm.
Safety and Warnings
Never Stop Abruptly: Suddenly stopping Brivaracetam can cause “Status Epilepticus” (prolonged, non-stop seizures). The physician will provide a gradual tapering schedule in case the drug needs to be eliminated.
Mental Health: Please inform your doctor if you have a history of depression or anxiety, as this medication may occasionally trigger adverse mood and behaviors.
Liver Function: Since this drug is metabolized in the liver, give a lower initial dose to those with hepatic impairment.
Pregnancy and Breastfeeding: When planning pregnancy, it is crucial to seek consultation from one’s neurologist, as control of seizures is paramount for both the woman and her baby.
Frequently Asked Questions (FAQ):
Q: What is the difference between Brivaracetam and Levetiracetam?
While both belong to the same family and act on the SV2A protein, Brivaracetam binds in a more selective manner and penetrates better into the brain. By virtue of its chemical structure, Brivaracetam seems to induce lesser behavioral side effects than Levetiracetam in some patients.
Q: Can I drink alcohol while on Brivaracetam?
We recommend not drinking alcohol, because it can enhance the sedative effect of the medicine leading to severe drowsiness and may result in seizures in some individuals.
Q: What to do if I miss a dose?
Take the missed dose as soon as possible. Nevertheless, if it is already time for your next dose, skip the missed one; taking two doses to “catch up” is prohibited.
Q: Does Brivaracetam affect driving?
Yes, brivaracetam can cause dizziness and blurred vision, especially during the first few weeks of treatment. Do not drive a car, use heavy machinery, or engage in any other hazardous activity until you…make sure that you know how the medication affects you in terms of coordination.
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Are children safe for the use of this drug?
Brivaracetam is approved by the FDA for partial-onset seizures in pediatric patients one month and older. Specialist dosing is determined based on their body weight as relates to child patients.
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Storage
Keep at room temperature (beneath 30°C) in a warm, dry place. Don’t allow your medication to be near to sunlight and keep it in a place where children can be prevented to reach.
Disclaimer: This is for information purpose only and not at all a replacement for professional medical advice. Please consult your healthcare provider before making any changes in how you take this medication.
