CINNARIZINE

Overview
:Cinnarizine is an antihistamine and calcium channel blocker commonly used to manage balance disorders such as vertigo, dizziness, and motion sickness. It works by reducing abnormal stimulation in the inner ear and brain that causes these symptoms.

Classification:Antihistamine (H1 receptor antagonist)

Uses:Cinnarizine is used to treat and prevent conditions related to balance and motion. It is commonly prescribed for vertigo, dizziness, motion sickness, and nausea caused by inner ear problems like Meniere’s disease or labyrinthitis. It helps control the feeling of spinning, vomiting, and unsteadiness. Cinnarizine is also used to improve blood flow in the brain and inner ear, which can reduce symptoms like tinnitus (ringing in the ears) and hearing problems in some circulatory disorders.

How It Works:Cinnarizine works primarily as a selective calcium channel blocker and an H1 histamine receptor antagonist. It inhibits the influx of calcium ions into vascular smooth muscle cells, particularly in the inner ear and brain, which helps reduce vestibular stimulation and improves microcirculation. By blocking H1 receptors in the central nervous system, cinnarizine reduces symptoms of nausea, vomiting, and vertigo associated with motion sickness and vestibular disorders. Additionally, it has mild sedative and anti-dopaminergic properties, which contribute to its effect in managing balance disorders, though these effects also account for potential side effects like drowsiness and extrapyramidal symptoms in long-term use.

Dosage:As prescribed by your doctor.

Side effects:

Drowsiness or sleepiness

Stomach discomfort

Dry mouth

Stomach discomfort

Nausea

Precautions:

Cinnarizine should be used with caution in elderly patients, as they are more prone to central nervous system side effects such as sedation, confusion, and extrapyramidal symptoms. It is contraindicated or should be avoided in patients with Parkinson’s disease due to its dopamine receptor blocking properties, which may worsen motor symptoms. In patients with hepatic impairment, careful monitoring is advised because cinnarizine is metabolized in the liver. While no major dose adjustment is typically required in renal impairment, caution is recommended in severe cases. The drug has sedative properties and may potentiate the effects of alcohol and other CNS depressants; therefore, patients should avoid such combinations. It can impair alertness and coordination, so activities like driving or operating machinery should be avoided until the patient’s response to the medication is known. Prolonged or long-term use should be monitored, as it may lead to weight gain, depression, or extrapyramidal reactions. Cinnarizine should only be used during pregnancy and lactation if clearly indicated and under strict medical supervision, as safety in these conditions has not been well established.

Disclaimer:This content is for informational purposes only. Always consult a healthcare provider for medical advice and proper dosa