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Sevelamer Hydrochloride: Combatting High Phosphorous Levels
Sevelamer Hydrochloride is considered to be a phosphate binder for managing serum phosphorus concentrations in chronic kidney disease (CKD) patients on dialysis. When the kidneys fail, there can be an accumulation of phosphorus in the blood, which can lead to severe complications like bone disease and blood vessel calcification.
The Mode of Action
Sevelamer is not ingested into the blood like other drugs, but it is used locally in the digestive tract. It binds the phosphate in food and acts like a sponge by removing them. Therefore, the bound phosphate becomes a waste product and outflows from the body, which finally minimizes the amount entering the blood.
Ample Health
Bone Health: Minimizes calcium dissipation from the bones and averts bone fracture.
Cardiovascular Support: Sevelamer averts the hardening of arteries by controlling phosphorus.
Active Control: Proved to be able to deal with high phosphate levels in the body, in hemodialysis and peritoneal dialysis.
Dosing and Usage
Take with Food: It should be taken during meals for effective phosphate-binding in the diet.
Whole tablet is to be swallowed: The medication tablet must be swallowed whole and not crushed, chewed, or broken as to avoid interference with its mode of action.
Take it as per your physician: Generally, it is prescribed three times a day with snacks or meals, depending on the serum phosphorus level.
Most Common Side Effects
GI side effects are seen with acclimatization. These include:
Nausea and vomiting
Periodic constipation/diarrhea
Belching, bloating, and flatulence
Upper abdominal pain
Important Note: Seek medical advice in case of severe constipation and severe colicky abdominal pain.
Frequently Asked Questions
Q: Can Sevelamer be taken on an empty stomach?
No. Sevelamer is meant to bind to dietary phosphorus; hence, it is ideally taken with meals.
Q: Will it affect my vitamin levels?
Yes, in some cases. Sevelamer may interfere with the absorption of fat-soluble vitamins (A, D, E, and K) and folic acid. Your doctor may recommend supplements if needed.
Q: Can I take other medications with Sevelamer?
Some drugs may bind with Sevelamer. It is recommended to take other medications at least 1 hour before or 3 hours after Sevelamer. Always consult your pharmacist or doctor.
Q: Can I be sure it’s safe during pregnancy?
Consult your doctor if you are pregnant. While it is not significantly absorbed into the bloodstream, it may affect the absorption of essential nutrients.
Q: What should I do if I miss a dose?
If you miss a dose with a meal, skip it and return to your regular schedule. Do not take a double dose.
Safety Checklist
Allergy Alert: Do not take if you are allergic to Sevelamer Hydrochloride.
Bowel Obstruction: Inform your healthcare provider if you have a history of bowel blockages or obstipation.
Recent Surgery: Inform your healthcare provider about any recent major stomach or intestinal surgery.
