SILDENAFIL CITRATE

Overview:

Sildenafil citrate (commonly known by the brand name Viagra) is a medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH).

Classification:

Phosphodiesterase(PDE) inhibitors

Uses:

It relaxes blood vessels in the lungs, improving blood flow and reducing the workload on the heart.

It helps men achieve and maintain an erection by increasing blood flow to the penis when sexually stimulated.

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How It Works:

Sildenafil citrate is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). In the presence of sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum of the penis, activating guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). cGMP induces smooth muscle relaxation in the corpus cavernosum by decreasing intracellular calcium levels, leading to vasodilation and increased penile blood flow, resulting in erection. Sildenafil enhances erectile function by inhibiting the degradation of cGMP by PDE5, thereby prolonging its vasodilatory effects. It has minimal effect in the absence of sexual stimulation and does not directly cause penile erection.

Dosage:

As prescribed by your doctor.

Side Effects:

Headache

Nasal congestion

Flushing (warmth or redness in the face, neck, or chest)

Dyspepsia (indigestion or upset stomach)

Dizziness

Visual disturbances

Precautions

It is important to inform your doctors that you take sildenafil.Dose adjustment may be needed. Start with the lowest dose in severe impairment.Warn patients to seek emergency help for erections lasting >4 hours, which can lead to permanent damage.

Disclaimer:

This content is for informational purposes only. Always consult a healthcare provider for medical advice and proper dosage.