Ryaltris-AZ Nasal Spray should be used exactly as prescribed by your doctor. Do not use it more often or for longer than recommended. Normally you should blow your nose gently before using it, keep one nostril closed while applying the medicine into the other, and then sniff hard to make sure it reaches deep into the nose. Then repeat for the other nostril. It provides relief very quickly and can last for several hours. If you use this medicine too often or for too long, it may worsen your symptoms rather than improve them.